Articles
| Open Access |
https://doi.org/10.37547/ijasr-03-09-25
THE ROLE OF CIN-DIAG RAPID TEST IN SCREENING FOR CERVICAL EPITHELIUM PATHOLOGY
Abstract
This article is aimed at identifying the pathology of the cervical epithelium in the early diagnosis of cervical cancer using an express test. During the study 10716 women aged 25-65 years were examined (mean age 43.28±3.82 years). To increase the specificity and sensitivity of screening, local express tests were used, in particular, a modified CIN-Diag test. As a result, the use of the proposed algorithm for screening CC made it possible to detect metaplasia of the CC epithelium in the early stages (precancer) and reduce the need for colposcopy by 4.65 times.
Keywords
Cervical cancer, screening, CIN-DIAG test
References
Huh WK, Williams E, Huang J, Bramley T, Poulios N. Cost effectiveness of human papillomavirus-16/18 genotyping in cervical cancer screening. Appl. Health Econ. Health Policy. 2015; 13:95–107 IARC. Cervix cancer screening, Vol 10 (IARC, Lyon, 2005).
Ikenberg H, Bergeron C, Schmidt D, Griesser H, Alameda F, Angeloni C, et al. Screening for cervical cancer precursors with p16/Ki-67 dual-stained cytology: results of the PALMS study. J. Natl Cancer Inst. 2013;105:1550–1557.
Insinga RP, Glass AG, Rush BB. Diagnoses and outcomes in cervical cancer screening: a population-based study. Am. J. Obstet. Gynecol. 2004;191:105–113.
Jeong DH, Youm MY, Kim YN, Lee KB, Sung MS, Yoon HK, Kim KT. Promoter methylation of p16, DAPK, CDH1, and TIMP-3 genes in cervical cancer: correlation with clinicopathologic characteristics. Int J Gynecol Cancer. 2006;16(3):1234–1240.
Kang S, Kim J, Kim HB, Shim JW, Nam E, Kim SH, Ahn HJ, Choi YP, Ding B, Song K, Cho NH. Methylation of p16INK4a is a non-rare event in cervical intraepithelial neoplasia. Diagn Mol Pathol. 2006;15(2):74–82.
Luttmer R, De Strooper LM, Berkhof J, Snijders PJ, Dijkstra MG, Uijterwaal MH, et al. Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study) Int. J. Cancer. 2016;138:992–1002.
Ma YT, Collins SI, Young LS, Murray PG, Woodman CB. Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study. Br J Cancer. 2011;104(9):1500–1504.
Mabuchi S, Isohashi F, Yokoi T, Takemura M, Yoshino K, et al. A phase II study of postoperative concurrent carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy followed by consolidation chemotherapy in surgically treated cervical cancer patients with positive pelvic lymph nodes. Gynecol Oncol. 2016;141:240–246. doi: 10.1016/j.ygyno.2016.02.011.
Spathis A, Aga E, Alepaki M, Chranioti A, Meristoudis C, Panayiotides I, Kassanos D, Karakitsos P. Promoter methylation of p16(INK4A), hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence. Infect Dis Obstet Gynecol. 2011;2011:927861.
Yang HJ, Liu VW, Wang Y, Chan KY, Tsang PC, Khoo US, Cheung AN, Ngan HY. Detection of hypermethylated genes in tumor and plasma of cervical cancer patients. Gynecol Oncol. 2004;93(2):435–440.
Yang HJ, Liu VW, Wang Y, Tsang PC, Ngan HY. Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. BMC Cancer. 2006;6:212
Zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst. 2000;92(9):690–698.
Talukdar FR, Ghosh SK, Laskar RS, Mondal R. Epigenetic, genetic and environmental interactions in esophageal squamous cell carcinoma from northeast India. PLoS One. 2013;8(4):e60996.
Tang B, Li Y, Qi G, Yuan S, Wang Z, Yu S, Li B, He S. Clinicopathological Significance of CDKN2A Promoter Hypermethylation Frequency with Pancreatic Cancer. Sci Rep. 2015;5:13563.
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.
Torres KL, Marino JM, Pires Rocha DA, de Mello MB, de Melo Farah HH, Reis R, D. S, et al. Self-sampling coupled to the detection of HPV 16 and 18 E6 protein: A promising option for detection of cervical malignancies in remote areas. PLoS ONE. 2018;13:e0201262.
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Copyright (c) 2023 Dilfuzahon Zakirjanovna Mamarasulova, Dilbarkhon Abdulkosimovna Urmanbaeva, Doniyorbek Shukhratbekovich Khasanov, Sherzodjon Takhirovich Abdukodirov
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