Amphotericin B is a potent antifungal drug used for the treatment of various fungal infections. However, its clinical use is limited due to its poor solubility, high toxicity, and low bioavailability. Transfersomes, a type of deformable liposomes, have emerged as a promising drug delivery system for enhancing the efficacy and safety of Amphotericin B. In this study, we aimed to formulate, develop, and evaluate a transfersomal gel of Amphotericin B for improved drug delivery and enhanced therapeutic outcomes. The transfersomes were prepared using a thin-film hydration method and characterized for their size, morphology, entrapment efficiency, and stability. The transfersomal gel was formulated by incorporating transfersomes into a suitable gel base. The developed transfersomal gel was evaluated for its physicochemical properties, drug release profile, and antifungal activity. The results showed that the transfersomes exhibited a small and uniform size, high entrapment efficiency, and good stability. The transfersomal gel demonstrated controlled drug release and improved antifungal activity compared to the conventional gel formulation. These findings suggest that the transfersomal gel of Amphotericin B holds promise as a potential drug delivery system for the effective treatment of fungal infections.

Early detection of cancer plays a crucial role in improving patient outcomes and survival rates. Non-invasive and cost-effective methods for cancer screening are highly desirable. This comprehensive study focuses on the analysis of urine as a potential diagnostic tool for early detection of various cancers. Urine samples from a large cohort of individuals were collected and analyzed using advanced molecular and biochemical techniques. The study investigated specific cancer biomarkers present in urine that could indicate the presence of different types of cancers. The results demonstrated promising findings, showing significant associations between certain biomarkers in urine and specific cancer types. These findings highlight the potential of urine analysis as a non-invasive and accessible approach for early cancer detection, which could have significant implications for cancer screening and improving patient outcomes.

In the article, the advantages of quantum-chemical calculations in the study of the relationship between the structure and properties of matter were presented. In order to energetically justify the structure of the product formed as a result of the reaction of ferrocenecarbonic acid with p-aminobenzoic acid, the structure of the optimized structures was studied in the Gaussian 98 program. Their Hartree energies were determined and analytical data were reported.

This article talks about a new approach to teaching examples of world literature - culturology. Scientific studies on the etymology of the term culturology are considered. Practical conclusions are given about the cultural approach and the advantages of using it in the teaching of works of world literature.

Glipizide is an oral anti-diabetic medication commonly used to manage hyperglycemia in individuals with type 2 diabetes. In this study, we investigate the anti-hyperglycemic effect of glipizide implants in alloxan-induced diabetic rabbits. Alloxan induction is a well-established model for studying diabetes in animals. Implants containing glipizide were administered subcutaneously to the diabetic rabbits, and their blood glucose levels were monitored over a specified period. The study aims to assess the effectiveness of glipizide implants in reducing blood glucose levels and to evaluate the duration of the anti-hyperglycemic effect. Additionally, the study examines any potential adverse effects or complications associated with the glipizide implants. The findings of this study contribute to the understanding of the therapeutic potential of glipizide implants for the management of hyperglycemia in diabetic rabbits.

The article considers the object of research - a mental unit verbalized by various linguistic means (lexical, grammatical) and non-linguistic means-a CONCEPT. The term "concept" in Russian linguistics was borrowed from English literature in the mid-70s. The reason was the problem of adequate translation in the works of foreign authors.

This article is about the role of social policy in the realization of human value and social interests in society, and the author reflects on the role of socio-political reforms in glorifying human value in society and the importance of social protection mechanisms in ensuring human interests.

Facial biometrics have gained significant attention as a convenient and reliable means of user authentication in various applications. In this research article, we conduct a comprehensive analysis of non-cryptographic methods for binding software to facial biometric data of user identity. The objective is to explore the effectiveness and limitations of these methods in enhancing the security and reliability of information technology systems. The analysis considers various techniques used in the processing and analysis of facial biometric data, shedding light on their applicability and potential vulnerabilities. The findings of this analysis provide valuable insights for researchers, developers, and practitioners in the field of facial biometric authentication.

The article draws on the analysis of the concepts of “Youth Innovation activism”, “social problems” and “neighborhood”, and covers the issue of their interaction in detail. It was said that the participation of young people in the implementation of socio-economic processes and reforms on an innovative basis, a comprehensive analysis of their innovative activity from the point of view of today, makes it a special place in the processes associated with the comprehensive development of society.

Secure data sharing in the cloud is a critical concern to ensure the confidentiality and integrity of sensitive information stored in cloud environments. Key Aggregate Cryptosystem (KAC) is an emerging cryptographic technique that enables efficient and secure data sharing among multiple users in the cloud. This study focuses on the application of KAC for secure data sharing in cloud environments. The proposed approach utilizes a hierarchical key management scheme to generate and distribute encryption keys, allowing authorized users to access and decrypt shared data. The KAC framework ensures fine-grained access control and reduces the computational overhead associated with traditional encryption schemes. The study evaluates the security and performance aspects of the proposed approach through simulation and analysis, demonstrating its effectiveness in secure data sharing in the cloud.

The article describes the functional tasks of special subjects in the formation of professional competencies in the teaching of special subjects in professional educational institutions, the principles of teaching special subjects in modular education, the organization of theoretical and practical training.

Thermal expansion of substances. Deformation of a solid body, deformation and structure of a solid body, strength of a material, plasticity of a substance, brittleness of a substance, thermal expansion, linear expansion, thermal expansion of liquids, temperature dependence of water density, expansion when water freezes and its consequences.

This article explores the modern approaches to human resource management and their significance in the rapidly evolving business landscape. It discusses the key areas that have undergone transformation, including technology-driven HR practices, agile and flexible workforce management, employee development and upskilling, employee well-being and work-life balance, and promoting diversity and inclusion. The article highlights the role of technology in streamlining HR processes, improving efficiency, and creating a more engaging work environment.

In this article, a new field of modern linguistics, media-linguistics, researches the scientific discussion of the issues of media text, media speech stylistics. In this, the opinions on the research of the issue of media stylistics in English linguistics in world linguistics are expressed.

The article reveals the features of the content of the training module "MIMO technologies" for advanced training courses for teaching staff in the direction "Radioelectronic devices and systems", which were developed on the basis of the implementation of the Erasmus + project "New study program in space systems and communications engineering - Spasecom" at the Industry Center for Retraining and advanced training of teaching staff at the Tashkent University of Information Technologies named after Al-Khwarizmi.

The Korean language and culture are closely intertwined, with a rich history and unique features that have attracted global attention in recent years. This article provides an overview of the Korean language and culture, including their history, significance, and relationship to each other, as well as a more detailed exploration of their unique features, expressions, customs, traditions, and contemporary developments. The article also covers topics such as the global popularity of Korean culture, the challenges and opportunities of cultural exchange, and the future of Korean language and culture in a globalized world.

In the article, temperature adjustment in the environment of the TRACE MODE 6 software complex was studied by the method of model checking. Systems created in the TRACE MODE program are intended for information-measurement monitoring or management. Depending on the location or nature of the enterprise, the system architecture can be centralized or distributed. The ever-growing data is handled by the powerful SUBD RV SIAD 6 archiving technology. Systems created in TRACE MODE 6 software are very reliable for dynamic processes and are currently used in the petrochemical industry, metallurgy, energy, mechanical engineering, food industry, utilities, transport and scientific activities.

This work is devoted to the study of physical properties of inelastic scattering of light from different media as a result of intermolecular interaction. Intermolecular interaction plays a major role in studying the basic properties and physical nature of substances. In order to study the nature and mechanism of the intermolecular interaction of liquids, the process of formation of the combined scattering spectra of light, which is the most effective among various optical methods, and the optical properties were studied.

In this article, the content of the characteristics of the student's creative ability in the interdisciplinary horizontal-vertical teaching of biology is described mainly in terms of psychological, pedagogical, didactic requirements, criteria and principles.

This article discusses the role of the neighborhood in providing social education to children of preschool age. The role of the social environment in child education, its goals and tasks, and the tasks of the neighborhood self-governing organization are given.

The main purpose of this article is to describe the socio-economic life during the time of Amir Temur and to provide information about the wide use of agriculture in industry. The article focused on the development of agriculture and industry of Amir Temur.

This article contains the opinions and opinions of the authors regarding the fact that the Zomin oasis has become one of the cradles of ancient civilization and culture, its convenient geographical location and nature, and the role of the Great Silk Road in the socio-economic life of the population.  

This article presents a review of scientific literature and viewpoints on the issue of corporate governance and its effectiveness. The specific features of economic development in Uzbekistan demonstrate the importance of managerial activities in various economic sectors. Therefore, corporate governance occupies a significant place in the methodology of scientific research on corporate governance within the overall management system. The absence of a unified definition that can be applied to understand the underlying concept of corporate governance has provided the basis for the scientific exploration of two models of corporate governance in this article - the Anglo-American and Continental models.

In this topic, information is given about the concept of temperament in clinical psychology. The most important characteristics of human temperament are considered to be impressionability and impulsivity, which includes all the above parameters, and impressionability is equal to emotion, the power of motivation, and they master the motor domain, the speed of action, and maintaining effective power closeness to the meaning of impulsivity, distinguished by its stability, is described about the state of its characteristic in terms of the dynamic characteristics of a person's mental activity.

Currently, obtaining reliable data and its quick analysis has become the most important condition for successful management. This is especially true if the object of management and its external environment are a set of complex processes and factors that significantly influence each other. One of the most effective ways to solve problems arising in the field of management and organization is the use of cognitive modeling in the digital economy, which is the subject of study in this article.

Today, the development of the digital economy has become one of the urgent issues in the development of the financial sector. In the conditions of the digital economy, advanced technologies, digital transformation, artificial intelligence, blockchain and virtual reality are of great importance. The technologies considered in this article are the latest technologies of the digital economy, the emergence and development of which have a strong impact on all sectors of the economy and social activities, including production, health, education, financial services, transportation and other areas. showed a secret.

In the present era, when digitization processes are rapidly progressing in all areas of our life, the most important and decisive technology of the digital economy is the digital platform. Currently, digital business ecosystems are functioning as an integral part of the digital economy. It is no secret that digital business ecosystems are being actively used in every sphere of our life and are facilitating the way of life of mankind. Nowadays, every person who can use electronic devices and the Internet can use an ecosystem in his work or personal life, which will create a number of reliefs for him. Based on this approach, this article describes digital platforms, digital business ecosystems, their capabilities and role in our lives today, and the purpose of creating digital ecosystems.

The digital economy is the result of the analysis of these processes based on the use and processing of large amounts of data, it is an activity in which digital information is considered the main factor of production, which allows to significantly increase the efficiency of storage, sale and delivery of various productions, technologies, equipment, goods and services. This article discusses foreign experience and innovation in the development of the digital economy. In today’s fast-paced global economy, the digital economy is at an early stage of development, and it will only take a few years for our world to fully transition to digital information.

The term “digital economy” refers to the use of information technology to create, adapt, market and consume goods and services that are based on the use of information technology, in order to make money. A number of digital research areas have been explored in the past few years, including digital banking, e-commerce, virtual education, smartphone apps, and collaboration platforms. During the past few decades, there has been no doubt that the world we live in has been changing steadily in many ways. Among the key factors that have driven these changes has been the Digital Revolution, which is one of the key drivers of these changes. It would be more accurate to say that the purpose of digital transformation is not to search for unicorns on the Internet, but rather to use the newest technology to do what you do already in a more efficient and effective manner. As a result of digital technologies, many countries are in a position to enhance their competitiveness and promote economic growth by increasing their use of these technologies. As a definition, the digital economy refers to the economic activity that results from billions of online connections that occur every day between people, businesses, devices, data, and processes. A key component of the digital economy is hyperconnectivity, which is the increasing interconnection of people, organizations, and machines that is a result of the Internet, mobile technology, and the internet of things (IoT). There is no doubt that the digital economy is taking shape and upending conventional notions about how businesses are structured; how they interact; and how they provide services, information, and goods to consumers.

Today, the development of the digital economy has become one of the urgent issues in the development of the financial sector. In the conditions of the digital economy, advanced technologies, digital transformation, artificial intelligence, blockchain and virtual reality are of great importance. The technologies considered in this article are the latest technologies of the digital economy, the emergence and development of which have a strong impact on all sectors of the economy and social activities, including production, health, education, financial services, transportation and other areas showed a secret. In this article, the importance of the role of information technology in the development of the economy of Uzbekistan, together with various economic reforms, has been demonstrated through reforms in the world and in our country.

Today, the world financial and banking system is primarily digital electronic payment systems of the economy, cryptocurrencies and without intermediaries due to the rapid growth of the market share of elements such as lending revolutionary changes are taking place. First of all, the rapid growth of mobile payments and credit volume is observed. It is known that, unlike traditional fields of activity, the market value of Internet companies does not have any material basis, and the more useful information the company has collected, the more it can produce a product or service will be cheaper. Currently, it does not have its own offices and ATMs rapid growth in the number of digital banks and financial institutions being observed. In this article, the role of the digital economy today and in the context of the digital economy information on ways to further reform the banking system is provided.

Climate change, which was once considered a simple natural phenomenon, has become a global threat in the world today. Even the world community recognizes this danger as one of the most serious problems facing humanity. The countries that did not take measures against it in time will have to mobilize large funds against the serious consequences of climate change. This article examines the impact of the economy on the environment, the interdependence of the economy and the environment, the impact of risks and damages arising from economic activities on the environment. It also talks about the importance and benefits of the “green” economy in reducing environmental risks and damage to nature. At the same time, the experience of foreign countries in the use of eco-innovations and eco-investments in the transition to a “green” economy has been extensively researched.

Nowadays, the concept of digital economy has appeared in the economic theory and practice of a number of countries. It was characterized by the rapid development of digital technologies, the revolution in the information sector, and the acceleration of the globalization of the economy. The efficiency of their use has been translated into increasing knowledge, and socio-economic relations are expanding more and more.

In the article, current issues of science and the development of a diverse economy were scientifically analyzed. Innovation in education is the improvement of the quality and effectiveness of education through a set of new methods and tools introduced for use in the educational process. In many places, learning or innovation in any process cannot be innovation. Innovation will need to be made, analytics, convenience and breakthroughs in this embedded process.

Simple didactic materials used in engineering education are models, their advantages are that they can demonstrate movement, hold hands and control their movement. In the process of use, future engineers can easily visualize the complex objects being studied, methods of their preparation in an educational institution and the definition of layouts are presented.

The main purpose of this article is to reveal the socio-economic and political life in the time of Amir Temur with examples. The article focused on Timur's beautification, agricultural and irrigation works.

This scientific article presents a comprehensive comparative analysis of modern terms in the Uzbek and English languages. With the rapid advancements in technology, globalization, and cultural interactions, languages undergo adaptations to accommodate new concepts. This study investigates the linguistic expressions and cultural adaptations of contemporary terms in two distinct languages, highlighting the similarities and differences that emerge from these processes. Through the examination of various thematic categories, this article contributes to our understanding of language evolution and cross-cultural communication.

In 2020-2023, a study was conducted to study the distribution and biological diversity of steinernematid and heterorabtid entomopathogenic nematodes (EPN) in three regions of Uzbekistan.

Steinernematids are more common than heterorhabditids, and S. feltiae is the most common species. Sampling sites were grouped into 4 habitats: barren land, gardens, fields, residential homesteads; the soil composition of each plot was determined and the influence of the habitat and soil composition of each species was evaluated.

Today, the demand for energy resources is structurally changing, especially in the transition from hydrocarbon resources to renewable sources, the development of hydrogen energy is becoming an urgent issue. In this article, the economic indicators of the D-243 engine by adding hydrogen additive as fuel are determined.

Today, in the transition to digital economic educational institutions as an organization at the forefront of intellectual development of the country, are in conditions of necessary bridges of operational transformations. Serious digitalization of all processes that make up modern educational system and its influence on the way teaching is conducted is explored in the following article.