GENETIC MECHANISMS OF DEVELOPMENT OF NEUROPATHIES IN MYELOMA

The article discusses the genetic mechanisms underlying the development of neuropathies in myeloma - a tumor of bone marrow plasma cells. Although these mechanisms are not yet fully understood, research points to several potential factors, including mutations in myeloma cell lineage-associated genes such as the MMSET/NSD2 gene and transcription factors such as IRF4. Another important factor is the immune system disorder that accompanies myeloma and can lead to damage to nerve fibers. More detailed studies are required to fully understand the genetic mechanisms of the development of neuropathies in myeloma.