Integrated Nanotechnology for Food Safety: Advanced Nanomaterials and Dual-Mode Sensing Platforms for Pathogen Detection and Adulterant Mitigation
Keywords:
Nanobiosensors, Metal Oxide Nanoparticles, Food Safety, SERS DetectionAbstract
The integrity of the global food supply chain is increasingly compromised by biological pathogens, heavy metal contamination, and intentional chemical adulteration. Traditional analytical methods, while accurate, often lack the speed and field-applicability required for modern safety standards. This research explores the convergence of nanotechnology and analytical chemistry to provide high-sensitivity solutions for food monitoring. We analyze the efficacy of metal oxide nanoparticles-including magnesium oxide (MgO), zinc oxide (ZnO), and aluminum oxide as potent antimicrobial agents against drug-resistant strains such as Candida albicans and various Gram-negative bacteria. Furthermore, the study details the development of dual-mode detection platforms, specifically colorimetric and Surface-Enhanced Raman Scattering (SERS) sensors utilizing Au@AgPt nanoparticles for trace mercury ion identification. The integration of immunomagnetic separation and microfluidic Loop-Mediated Isothermal Amplification (LAMP) is evaluated for the rapid detection of foodborne pathogens like Listeria monocytogenes and Salmonella spp. By examining the physicochemical interactions at the nano-bio interface, this article provides a comprehensive theoretical framework for the deployment of smart nanomaterials in food safety. The findings suggest that while metal oxide nanoparticles offer promising antifungal and antibacterial properties through reactive oxygen species (ROS) generation, the future of food quality assurance lies in multifunctional, label-free platforms and digitalized monitoring systems.
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