Throughout the world, in recent years there has been a clear increase in the number of kidney diseases in both the adult (12.2) and pediatric populations (6.10). The frequency of urinary system infections (UTI) and their share in the nosological structure of kidney diseases is also increasing to 75.6% (9). The prevalence of pyelonephritis (PN) itself was 32.1:1000, i.e. 43.4% of the total number of nephrology patients. Latent forms of PN pyelonephritis, detected during active examination, are 3 times more common than manifest forms identified by referral. According to V.I. Naumova (1991), 15.3% of chronic renal failure (CRF) developed in childhood is the outcome of secondary chronic pyelonephritis.

Chronic renal failure, pyelonephritis, children

Alchinbaev M. K., Sultonova B. G., Karabaeva A. J. Surunkali pielonefrit bilan og'rigan bemorlarda funktsional buyrak zaxirasi. // Nefrologiya. - 2001. 5-jild, 2-son. 71-74 betlar.

Yesayan A.M., Buyrakning to'qima renin-angiotensin tizimi. nefroproteksiyaning yangi strategiyasi / / nefrologiya.- 2002. 6-jild, 3-son.10-14 betlar

Ishkabulova G. Dj, Kholmuradova Z.E., & Rahmonkulov Sh. I. (2023). CHANGE OF FUNCTIONAL KIDNEY RESERVE IN CHILDREN IN DYSMETABOLIC NEPHROPATHIES. International Journal of Medical Sciences And Clinical Research, 3(10), 47–54.

Kartamisheva N. N., Chumakova O. V., Kucherenko A. G. Surunkali pielonefrit va surunkali interstitsial nefritning rivojlanish omillari / / pediatriya. G. N. Speranskiy 2004 Yil. №5.50-53 betlar.

Gulchekhra Dzhonhurozovna Ishkabulova, Zilola Ergashevna Kholmuradova CHANGE OF THE STATE OF THE FUNCTIONAL RESERVE OF KIDNEYS IN DYSMETABOLIC NEPHROPATHIES (URATURIA) IN CHILDREN // Scientific progress. 2021. №6.

Muhin N. A., Balkarov I. M., Moiseev S. V. va boshqalar. Surunkali progressiv nefropatiyalar va zamonaviy insonning turmush tarzi / / ter. arx. --2004.-№9.5 10 sahifa.

Ni A. N., Luchaninova V. N., Popova V. V., Simeshina O. V. Bolalardagi dismetabolik bilan nefropatiyalarning gomeostatik buyrak funktsiyalarining tuzilishi / / nefrologiya.-2004.8-jild, 2-son.-C. 68-72.

Rogov V. A., Kutirina I. M., Tareyeva I. E. va boshqalar. Nefrotik sindromda buyraklarning funktsional zaxirasi / / ter. arx. - qaniydi? 1996.-No6.-C. 55-58.

Smirnov A. V., Yesayan A. M., Kayukov I. G. Surunkali buyrak kasalligi: yakdillik birligi yo'lida //nefrologiya.-2002.6-jild, 4-son.11-17 betlar.

Ishkabulova G. D. et al. MODERN METHODS FOR ASSESSING THE COURSE, TREATMENT, AND PROGNOSIS OF CHRONIC RENAL FAILURE IN CHILDREN //British Medical Journal. – 2023. – Т. 3. – №. 1.

Epstein M. Aldosterone as a mediator of progressive renal disease: Pathogenetic and clinical implications ||Am, J. Kidney Dis.-2001; 237:677-688.

Mazzali M., Hyghes J.; Kin Y. et. al. Elevated uric-acid increases blood pressure in the rat by a novel crystalindependent mechanism Hypertension.- 2001; 38: 1101-1106.

Ишкабулова Г.Д., Холмурадова З.Э. Фосфолипидная структура и состояние перекисного окисления липидов эритроцитарных мембран у новорожденных от матерей с гестозом, сочетанным хроническим пиелонефритом. //Журнал Биомедицины и практики .2022.-№3 –С71-77.

Yuryeva E. A., Dlin V. V. “Nefrologiya diagnostik qo'llanmasi,".-2002.-95c.

Ishkabulova G.D.,Kholmuradova Z.E. Homiladorlik surunkali pielonefrit va gestoz bilan kechgan onalardan tug'ilgan chaqaloqlarda fosfolipid tuzilishi va eritrotsit membranalarining lipid peroksidlanish holati //Журнал Биомедицины и Практики. – 2022. – Т. 7. – №. 3.

Ishkabulova Gulchexra Djankurazovna, & Kholmuradova Zilola Ergashevna. (2022). FUNCTIONAL STATE OF THE KIDNEYS IN NEWBORN BORN FROM MOTHERS WITH PRE-ECLAMPSIA. World Bulletin of Public Health, 14, 75-78.

Ishkabulova G. J. et al. Сomparative assessment on the effect of different methods of corrective therapy on lipid metabolismand homeostatic renal function //European Journal of Molecular and Clinical Medicine. – 2020. – Т. 7. – №. 3. – С. 2794-2800.