Abstract
Amphotericin B is a potent antifungal drug used for the treatment of various fungal infections. However, its clinical use is limited due to its poor solubility, high toxicity, and low bioavailability. Transfersomes, a type of deformable liposomes, have emerged as a promising drug delivery system for enhancing the efficacy and safety of Amphotericin B. In this study, we aimed to formulate, develop, and evaluate a transfersomal gel of Amphotericin B for improved drug delivery and enhanced therapeutic outcomes. The transfersomes were prepared using a thin-film hydration method and characterized for their size, morphology, entrapment efficiency, and stability. The transfersomal gel was formulated by incorporating transfersomes into a suitable gel base. The developed transfersomal gel was evaluated for its physicochemical properties, drug release profile, and antifungal activity. The results showed that the transfersomes exhibited a small and uniform size, high entrapment efficiency, and good stability. The transfersomal gel demonstrated controlled drug release and improved antifungal activity compared to the conventional gel formulation. These findings suggest that the transfersomal gel of Amphotericin B holds promise as a potential drug delivery system for the effective treatment of fungal infections.